Open access
Oct 2026
Profibrotic activation of fibro-adipogenic progenitors impairs myogenesis through extracellular matrix synthesis and soluble factors
The primary source of fibrosis in skeletal muscle is fibro-adipogenic progenitors (FAPs) which deposit extensive extracellular matrix (ECM). FAPs are key in supporting regeneration and myogenesis in healthy muscle but become pathogenic in fibrosis. The goal of this study was to determine the effect of fibrotic FA...
Herman Huang, Taryn Loomis, Perri Gish et al.
· Skeletal Muscle · 0 citations