Author

L. Schmidt

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Open access Sep 2026

Role of Nuclear SUMO-Targeted Ubiquitin Ligase Uls2 (Slx5-Slx8) in Quality Control of Cytosolic Proteins

The interplay between the posttranslational modifiers SUMO and ubiquitin mediates the degradation of proteins. This crosstalk is conveyed by SUMO-targeted ubiquitin ligases (STUbLs). The best-studied STUbL in Saccharomyces cerevisiae is the heterodimer Slx5-Slx8 (Uls2). Uls2 mainly resides in the nucleus and is involve...

Friederike Profe-Austermann, Lennard-Maximilian Döring, L. Schmidt et al. · Biomolecules · 0 citations

Open access Sep 2026

Pulsed-SILAC in single mouse embryos reveals early embryonic protein synthesis dynamics and phosphosite regulation

Early embryogenesis relies extensively on maternally deposited products until zygotic genome activation, yet the dynamics for the synthesis of new proteins in mammalian embryos remains poorly characterized. To address this, we applied pulsed stable isotope labelling by amino acids in cell culture (pSILAC) combined with...

L. Schmidt, Maico Y. Lechner, Javier Martín-González et al. · bioRxiv · 0 citations

Open access Sep 2026

Spatial proteomics identifies FXYD6 as a dual-site protein of neuromuscular junction in the diaphragm

Morphological studies of the diaphragm have provided a detailed view of its architecture, which consists of parallel skeletal muscle fibers and a central ring of neuronal innervation that includes neuromuscular junction (NMJ) units. NMJs are disease-vulnerable synapses; thus, analysis of the NMJ is essential to underst...

Nitin Eapen, L. Schmidt, M. Saynisch et al. · Communications Biology · 0 citations