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L. Schmalbrock

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Open access Aug 2026

Recurrent non-canonical proteoforms in acute myeloid leukemia identified by integrative proteogenomics

Reference proteomes incompletely represent proteins translated in cancer, leaving tumor-specific proteoforms outside the search space of conventional mass spectrometry (MS). Such “dark proteome” products may arise from genomic variation, aberrant transcription or splicing, and non-canonical translation, including micro...

L. Schmalbrock, Asher Preska Steinberg, Katarzyna Kulej et al. · 0 citations
Jul 2026

Information-seeking failures of large language models in agentic clinical reasoning

Large language models achieve high scores on medical knowledge assessments, yet clinical reasoning requires actively deciding what to investigate under uncertainty. We developed an agentic evaluation framework in hematologic oncology in which models must proactively request clinical data across three sequential rounds...

K. Braitsch, L. Schmalbrock, Theresa Weltermann et al. · 1 citation

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