Open access
Aug 2026
Lysine Oxidation by LOXL2 in Single Strands Versus Triple Helices: Implications for Collagen‐Related Diseases
ABSTRACT Collagen cross‐linking is essential for the structural integrity of the extracellular matrix. In several pathological conditions, the triple‐helical core of collagen is disrupted, and proline‐rich single strands occur. Lysyl oxidases (LOXs), enzymes that initiate cross‐linking by catalyzing the oxidative deami...
L. Poller, Tomas Fiala, H. Wennemers
· Angewandte Chemie · 0 citations