Author

L. Pan

2 papers indexed here

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Open access Sep 2026

An integrated platform for genome-wide functional analysis in Aspergillus niger through Ac/Ds insertion profiling and metabolic modeling

Genome-scale metabolic models guide rational strain engineering, while high-throughput insertional mutagenesis enables systematic investigation of gene function and condition-dependent growth requirements. However, a platform integrating high-density transposon insertion sequencing with matched stoichiometric, thermody...

Kang-Zhou Huang, Yi-Kun Lin, Bin Wang et al. · bioRxiv · 0 citations

Aug 2026

Engineering a versatile Aspergillus niger platform for efficient and scalable biosynthesis of polyketides.

Polyketides are a diverse class of natural products with broad pharmacological activities and substantial industrial relevance; however, their scalable biosynthesis is often constrained by inefficient heterologous expression platforms. In this study, a systematic evaluation of multiple microbial hosts identified Asperg...

Lin-Lin Yao, Rui Huang, Jiaping Liu et al. · Metabolic Engineering · 0 citations