Caffeine mitigates neuroinflammation and behavioral deficits induced by brain irradiation in mice.
PURPOSE Radiotherapy, a standard treatment for brain tumors, may induce cognitive deficits and neuroinflammatory responses, including increased pro-inflammatory cytokines, microglial and astrocytic reactivity, and alterations in neuronal markers. Caffeine, a widely consumed psychostimulant with reported anti-inflammato...