Lower occludin abundance is identified as the principal BBB-associated protein alteration in the 3xTg-AD model and exploratory evidence of increased BBB permeability at 3 months is provided.
K. M. Delgado-Minjares, C. Flores-Maldonado, J. Campos-Blázquez et al.· International Journal of Mol...· 0 citations
Blood-brain barrier (BBB) dysfunction is increasingly recognized as an early pathological event in sporadic Alzheimer’s disease (AD), which represents over 95% of cases. Vascular risk factors and cerebral insulin resistance are considered potential contributors to its initiation. This review synthesizes evidence availa...
Karen León-Arcia, Humberto Martínez-Orozco, Magdalena Guerra-Crespo et al.· Journal of Molecular Neurosc...· 0 citations
Background Obesity is a major risk factor for severe COVID-19, yet the immunological mechanisms by which it modifies disease progression remain incompletely characterized. We aimed to dissect the independent and interactive contributions of obesity and COVID-19 severity on circulating adipokines, cytokines, and immune...
Karla Jimena Basilio-Aguilar, Alfredo Pérez-Fragoso, Edith Cerón-Cruz et al.· Frontiers in Immunology· 0 citations
This integrated framework reframes PD as a disorder of impaired cellular maintenance rather than solely a consequence of late-stage degenerative processes, and provides a translational shift from mechanism-based biomarkers to early detection of mitochondrial failure and supports therapeutic strategies aimed at restorin...
Oscar Arias-Carrión, Magdalena Guerra-Crespo, L. O. Soto-Rojas et al.· Frontiers in Pharmacology· 0 citations
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