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Aug 2026

Spatial Transcriptomics of Micropapillary, Plasmacytoid, and Sarcomatoid Urothelial Carcinoma Reveals Distinct Molecular Landscapes.

PURPOSE Consensus molecular classes of urothelial carcinoma (UC) include basal/squamous (Ba/Sq), luminal papillary (LumP), luminal nonspecified (LumNS), luminal unstable (LumU), stroma-rich, and neuroendocrine (NE)-like. We aimed to determine the consensus molecular classifications of micropapillary (MP), plasmacytoid...

Ting Zhao, C. Nawrocki, Lin-Jie Xiong et al. · 0 citations
Jul 2026

CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer.

Immune aging impairs T cell-mediated tumor control as well as cancer immunotherapy outcomes. The most important drivers of T cell dysfunction in aged tumors remain unknown. We performed single-cell CRISPR screens to identify Dusp5 and Zfp219 as key regulators of CD8+ T cell persistence and effector differentiation with...

Alex C. Y. Chen, Keely Y. Ji, C. Yerinde et al. · 0 citations
Jul 2026

Comprehensive Spatial Transcriptomic Profiling of Cribriform, Intraductal, Atypical Intraductal Proliferation, and Ductal Adenocarcinoma of the Prostate.

Crib AAC, acinar IDC-P, and AIP demonstrated substantial transcriptomic similarity despite distinct differences, and DAC showed greater transcriptomic similarity to crib AAC than to non-crib AAC.

Ting Zhao, C. Nawrocki, Lin-Jie Xiong et al. · 0 citations

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