L. Nicolai

Procoagulant platelets in haemostasis and thrombosis.

Procoagulant platelets are characterized by sustained high cytosolic Ca2+, surface exposure of phosphatidylserine (PS) and P-selectin, and a balloon-shaped morphological transformation. These features strongly facilitate the generation of coagulation factor Xa and thrombin on the platelet membrane. Here, we provide a r...

Procoagulant platelets in hemostasis and thrombosis

Splenic regulation of systemic platelet activation state.

Platelets are essential to prevent blood loss and to orchestrate inflammation. Thrombotic complications of vascular disease and hyperresponsive platelets are associated with adverse outcomes, yet physiological mechanisms counteracting systemic platelet activation are poorly defined. In mice, we found that the spleen fi...