Discovery of 3-[(5-nitro-2-heteroaryl)methylene]-2-indolinone derivatives as highly potent antileishmanial agents and their bioactivation by NTR1 and 2.
A novel series of 2-indolinone derivatives bearing a nitroheteroarylmethylene moiety, including nitroimidazole, nitrofuran, and nitrothiophene at their 3-position, were synthesized as potential antileishmanial agents. The in vitro antileishmanial activity and cytotoxicity of these analogues were assessed using L.donova...