Circulating metabolic correlates of depressive symptoms are heterogeneous and strongly dependent on symptom phenotype and BMI-related metabolic context, suggesting that metabolic biomarkers in depression should be interpreted in relation to both symptom presentation and metabolic state rather than as uniform correlates...
S. Kurvits, N. Taba, Estonian biobank research team et al.· medRxiv· 0 citations
These findings extend the bradykinin hypothesis of ACEI-induced cough by implicating neurotensin-NTSR1 signalling, pinpoint CYP3A4*22 as a novel functional predictor of dCCB switching with potential for genotype-guided prescribing, and validate medication use trajectories as a framework for pharmacogenetic discovery.
F. Vaura, Kristi Krebs, T. Kiiskinen et al.· European Heart Journal· 0 citations
The results underscore the role of psychiatric genetic liability, beyond diagnosed psychiatric disorders, in contributing to both COVID-19 and other respiratory infection severity, and provide insights that may improve future risk stratification and public health strategies targeting respiratory viruses.
K. Kõiv, R. Askeland, L. N. Christoffersen et al.· Genome Medicine· 0 citations
This work developed a neural network model, nnCNV, to predict deletions in the CYP2C19 pharmacogene region from array intensity signals and demonstrated that long-range information, which cannot be utilized by hidden Markov models, can improve CNV calling.
Burak Yelmen, R. Hofmeister, Viido Kaur Lutsar et al.· bioRxiv· 0 citations
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