Open access
Sep 2026
The paracrine Ephrin A4/BMP4 feed-forward loop sustains a tumor–CAF vicious cycle in osteosarcoma
Advanced osteosarcoma (OS) remains a clinical challenge due to its aggressive behavior and poor prognosis. Cancer-associated fibroblasts (CAFs) have been shown to contribute to tumor progression, but the tumor–CAF crosstalk in OS is still poorly defined. Elucidating these interactions could reveal novel therapeut...
Giorgia Giordano, Cristina Tucciarello, E. Gucciardo et al.
· Cell Communication and Signa... · 0 citations