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Oct 2026

Abstract B100: Germline genetics of chronic inflammation and breast cancer risk in Peru: Building population-specific resources for precision prevention in Latin America

Breast cancer is the leading cause of cancer-related mortality among women, particularly in Low and Middle-Income Countries (LMICs), including Peru. Reportedly, the Peruvian population possess substantial Indigenous American ancestry, which remains underrepresented in genomic studies. Chronic inflammation contributes...

Solange R. Paredes-Moscosso, Xiao-Song Huang, Amanda F. Corpuz et al. · 0 citations
Open access Sep 2026

Breast Cancer–Protective Genetic Variant Common in Women of Indigenous American Genetic Ancestry Is a cis-eQTL for RMND1, ARMT1, and CCDC170 in HER2-Enriched Tumor Subtypes

Results suggest that in breast cancer tissue from Peruvian patients, rs140068132 influences the expression of multiple genes in a subtype-specific manner, likely acting through a regulatory element at 6q25 that modulates gene expression in cis depending on cellular context.

Valentina A. Zavala, Xiao-Song Huang, S. Casavilca-Zambrano et al. · 0 citations

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