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Author

L. Maragliano

2 papers indexed here

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Open access Sep 2026

Controlled Blood-Brain Barrier Modulation by a High-Affinity Claudin-5 Peptide Binder

The blood-brain barrier (BBB) is a specialized interface that tightly regulates the exchange of molecules between the bloodstream and the brain. Its barrier function relies on a monolayer of brain endothelial cells sealed by tight junctions (TJs) that restrict paracellular flux through claudin-5 (CLDN5) multimeric comp...

Alessandro Berselli, Martina Trevisani, Giulio Alberini et al. · 0 citations
Open access Oct 2026

Structural and kinetic mechanisms of state-dependent potassium channel inhibition

The KCNQ1 (Kv7.1) potassium ion (K+) channel plays a critical role in cardiac repolarization, while loss- or gain-of-function mutations increase the risk of life-threatening arrythmias and sudden death. Like many channels, KCNQ1 exhibits state-dependent pharmacological properties with inhibitors such as UCL2077 display...

E. Kyriakis, Agnese Roscioni, Jodene Eldstrom et al. · 0 citations

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