L. Lyytikäinen

Polygenic risk for schizophrenia predicting age-specific fluctuations in depressive symptoms: Findings from the Young Finns Study.

Depressive symptoms in adolescence may represent intermediary phenotypes or transdiagnostic susceptibilities related to high polygenic risk for schizophrenia (PRSscz), which appears to explain age-specific fluctuations in depressive symptoms.

Diabetes mellitus and the risk of sudden cardiac death in patients with and without coronary artery disease

Diabetes is associated with sudden cardiac death (SCD), but evidence in patients without coronary artery disease (CAD) remains limited. SCD risk may vary by revascularisation strategy in diabetic patients with CAD. We retrospectively analysed 22,395 consecutive patients undergoing coronary angiography from...

Analysis of Genetic Risk Scores, Exercise Testing Data and Clinical Data for Prediction of Sudden Cardiac Death in the Fincavas Cohort

Adolescent weight gain trajectories and their associations with biological aging: a genetically informed study.

Higher level of adolescent BMI partly mediated the association between higher BMI-PRS and accelerated biological aging from late adolescence to middle adulthood, indicating that high BMI in adolescence may accelerate biological aging.

Meta-analysis of 49(cid:0)549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

This study illustrates that GWAS with high-scale imputation may still help to unravel the biological mechanism behind circulating lipid levels and identifies more new rare and low-frequency functional variants associated with circulating lipid levels.