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Author

L. Lo Piccolo

2 papers indexed here

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Open access Oct 2026

Multi-omics profiling identifies a metabolic and energetic signature associated with neuronal dENL/AF9 suppression in aged flies

Maintenance of neuronal function during aging requires metabolic adaptation, yet how metabolite-sensitive chromatin regulators contribute to this process remains unclear. YEATS-domain proteins, including ENL and AF9, recognize histone acylation marks and are positioned at the interface between cellular metabolism and t...

Ranchana Yeewa, Pitiporn Noisagul, Sivamoke Dissook et al. · 0 citations
Open access Sep 2026

Pre-symptomatic proteomic and metabolomic profiling identifies compensated ER-redox-metabolic adaptation and early nuclear vulnerability in neuronal ERO1L toxicity

Aging progressively challenges neuronal proteostasis, redox homeostasis, and metabolism, yet the molecular changes that precede functional decline remain poorly understood. Endoplasmic reticulum oxidoreductin 1 (ERO1), a key regulator of oxidative protein folding, links endoplasmic reticulum (ER) proteostasis with cell...

L. Lo Piccolo, Ranchana Yeewa, Puttachat Poound et al. · 0 citations

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