Discovery of D‐peptides that allosterically enhance SARS‐CoV‐2 3CLpro activity by stabilizing its monomeric state
The SARS‐CoV‐2 main protease (3CLpro) is an essential enzyme for viral replication and a major target for antiviral drug development. While its catalytic activity is known to require dimer formation, the mechanism by which it cleaves itself from the monomeric viral polyprotein remains to be further studied. In this stu...