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Author

L. Kiemeney

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Open access Oct 2026

Large-scale association study identifies lung cancer susceptibility copy number variants and their potential functional role in genetic instability.

BACKGROUND Genome-wide association studies (GWAS) have identified numerous lung cancer susceptibility loci based on single nucleotide polymorphisms (SNPs), yet a substantial proportion of heritability remains unexplained. We therefore evaluated germline copy number variants (CNVs) as an underexplored source of genetic...

Fei-Fei Xiao, Fei Qin, Xi-Zhi Luo et al. · 0 citations
Open access Aug 2026

Expected costs and benefits of genetic counselling and germline genetic testing in metastatic prostate cancer

Identifying pathogenic germline variants in men with metastatic prostate cancer is important for therapeutic options and for identifying relatives who may have a high cancer risk. To keep genetic testing costs manageable, it is important to identify which patients should be selected for testing. In this study, we compa...

M. Vlaming, L. Kiemeney, W. Koole et al. · 0 citations
Open access Aug 2026

Fruit and vegetable consumption, dietary and plasma carotenoids and risks of recurrence and progression in patients with non-muscle-invasive bladder cancer

Higher postdiagnosis fruit and vegetable consumption may have a beneficial role in NMIBC recurrence but not progression risk while no associations for dietary and plasma carotenoids were found.

A. Vrieling, Joann Kiebach, M. Balvers et al. · 0 citations
Meta-analysis Open access Aug 2026

Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk

A multi-population meta-analysis of genome-wide association studies, including 32,470 individuals with and 1,753,462 without bladder cancer, identifies 70 independent risk loci, of which 43 are novel, and uses experimental approaches to uncover how inherited variation influences this risk in the context of smoking.

L. Prokunina-Olsson, O. Flórez-Vargas, Michael G. Levin et al. · 0 citations
Open access Aug 2026

Lifestyle and dietary inflammation scores and risks of recurrence and progression among patients with non-muscle invasive bladder cancer.

A pro-inflammatory lifestyle and diet, and systemic inflammation, as measured by hsCRP, were not associated with NMIBC outcomes in the authors' cohort, yet, contributions from specific inflammatory processes or other biomarkers cannot be excluded.

Joann Kiebach, Claire S A D Kamps, E. Wesselink et al. · 0 citations

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