Open access
Oct 2026
Type 1 diabetes SIRPG risk variants increase SIRPγ expression and CD47 loss enhances CD8+ T cell cytotoxicity
Type 1 diabetes (T1D) risk variants within SIRPG influence transcript splicing and alter the expression of signal regulatory protein gamma (SIRPγ) on human T cells; however, the functional consequences of the risk variants remain poorly defined. Here, we demonstrate that peripheral blood mononuclear cells from individu...
Robert C. Sharp, Matthew E. Brown, Leeana D. Peters et al.
· npj Autoimmunity · 0 citations