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L. Hendriks

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Open access Sep 2026

Osimertinib Plus Platinum-based Chemotherapy in Patients With EGFR-Mutated Advanced NSCLC Post-progression on First-Line Osimertinib: ORCHARD.

BACKGROUND ORCHARD (NCT03944772) was a biomarker-directed, phase II, platform study conducted to characterize resistance mechanisms and evaluate novel treatment combinations in patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) following progression on first-line osimertini...

J. Goldman, J. W. Riess, Byoung Chul Cho et al. · 0 citations
Open access Sep 2026

Prognostic implication of malignant pleural metastases in stage M1a non-small cell lung cancer in a real-world Dutch cohort receiving chemotherapy and/or immunotherapy.

INTRODUCTION In the updated 9th TNM non-small cell lung cancer (NSCLC) staging edition, pleural and pulmonary metastases remain grouped within the M1a category, inferring similar prognostic implications. The aim was to evaluate the prognostic implication on overall survival (OS) of pleural versus contralateral pulmonar...

A. Noordhof, R. A. M. Damhuis, Kevin G. Blyth et al. · 0 citations
Review Open access Sep 2026

Early-stage non-small-cell lung cancer: emerging treatments and evolving challenges.

The treatment of early-stage non-small-cell lung cancer (NSCLC) has evolved substantially in recent years. For decades, curative-intent surgery followed by platinum-based chemotherapy remained the standard of care (SOC), despite delivering only modest gains in long-term survival. Current evidence from randomised trials...

Jordi Remon, T. Cascone, S. P. Saw et al. · 2 citations
Review Sep 2026

Targeted therapies in advanced non-small-cell lung cancer: new biomarkers and treatment strategies.

Recent advances in NSCLC with established alterations are summarized, including EGFR, ALK, ROS1, KRAS, BRAF, RET, HER2, MET, and NTRK, and emerging targets are discussed, and emerging targets, such as NRG1 fusions, MTAP loss, and SMARCA4 deficiency are discussed.

L. Hendriks, Jessica J. Lin, D. S. Tan et al. · 2 citations
Open access Aug 2026

AI-HOPE lung cancer: a multicenter real-world registry integrating artificial intelligence for metastatic non-small-cell lung cancer

By combining structured clinical variables and multimodal imaging data, the AI-HOPE Lung Cancer study aims to support refined risk stratification and treatment personalization, ultimately facilitating the responsible integration of AI into routine thoracic oncology practice.

F. Ogliari, M. Ferrara, J. Huijs et al. · 0 citations

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