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L. Hanakahi

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Review Open access Jul 2026

A new conceptual framework for PKD1 in ADPKD; integrating DNA structures and inflammation.

This synthesis supports a conceptual model in which intrinsic sequence-dependent mutational susceptibility at the human PKD1 locus may interact with localized inflammatory microenvironments characterized by oxidative stress and epithelial proliferation to contribute to recurrent somatic second-hit formation.

L. Hanakahi, Tara Subrahmanyan, Gregory B. Vanden Heuvel et al. · 0 citations

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