Author

L. H. Urner

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Open access Oct 2026

Modular Triethylene Glycol Decouples Antimicrobial Potency from Cytotoxicity in Membrane-Active Drugs

Cationic membrane-active drugs are an important focus of antibiotic research, yet their potential is often limited by poor selectivity. Here, we establish steric protection of cations by modular triethylene glycol as a chemical design framework to decouple antimicrobial potency from cytotoxicity. Using antipsychotics...

Marc Seewald, Marla Stamen, Jian Li et al. · JACS Au · 0 citations

Review Open access Oct 2026

Trends in optimizing antibacterial cationic amphiphiles

Abstract Cationic amphiphiles are investigated as antibacterials, yet their potential is often limited by host-cell toxicity. Bacterial and mammalian membranes share core physicochemical features that promote interactions with cationic amphiphiles. Selectivity is realistically understood as a relative property window....

Oladapo J. Olaosebikan, J. Babalola, L. H. Urner · Biological chemistry · 0 citations