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L. Gailīte

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Open access Sep 2026

FRANK: a pan-cancer RNA-seq classifier for childhood tumors with data-efficient learning

Accurate characterization of tumor subtype is of paramount importance in guiding treatment decisions in pediatric cancers. Here, we present FRANK (Fully-connected RNA-based Augmentation Neural Klassifier), a machine learning approach for classifying pan-cancer pediatric tumors. We curated a set of 11,467 transcriptomes...

K. Sablauskas, T. Kiseļova, L. Bardina et al. · 0 citations
Open access Sep 2026

Skeletal Muscle Transcriptomic Responses to Concurrent Training With Polyphenols in Ageing Adults: A Randomized Trial

ABSTRACT Background Transcriptomic adaptations of ageing skeletal muscle to concurrent resistance training (RT) and high‐intensity interval training (HIIT) remain insufficiently characterized. We investigated the effects of a 12‐week concurrent RT + HIIT intervention on the vastus lateralis transcriptome in middle‐aged...

A. Guadalupe-Grau, D. Gudra, D. Lismane et al. · 0 citations
Open access Aug 2026

Polygenic risk score for early identification of coronary artery disease in a real-world clinical setting within the Latvian patient population

Investigating the utility of genome-wide association study - derived PRS and pathway-specific PRS in the Latvian population and demonstrating superior discrimination compared to pathway-specific PRS found incorporation of PRS enhances early-onset CAD risk prediction.

E. Kanašniece, Elita Ozola, L. Bardina et al. · 0 citations
Open access Jul 2026

A Quantitative Assessment of MRI-Visible Perivascular-Space Burden Across the Cognitive Spectrum: Associations with APOE ε4 Status and Venous Sinus Volume

The findings of this cross-sectional observational MRI study support further study of venous sinus morphology as a potential contributor to MRI-visible PVS burden, while longitudinal and flow-sensitive studies are needed to clarify causality and glymphatic clearance mechanisms.

Gvido Kārlis Skuburs, Kristīne Šneidere-Pītersa, A. Platkājis et al. · 0 citations
Open access Jul 2026

Detection of miRNA in chronic spontaneous urticaria patients - pilot study

Although no subgroup-specific signatures were confirmed after correction for multiple testing, several candidate miRNAs were identified, supporting further investigation of miRNA-based biomarkers in CSU.

Lāsma Lapiņa, Katrīna Daila Neiburga-Vīgante, L. Gailīte et al. · 0 citations

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