Accurate characterization of tumor subtype is of paramount importance in guiding treatment decisions in pediatric cancers. Here, we present FRANK (Fully-connected RNA-based Augmentation Neural Klassifier), a machine learning approach for classifying pan-cancer pediatric tumors. We curated a set of 11,467 transcriptomes...
K. Sablauskas, T. Kiseļova, L. Bardina et al.· medRxiv· 0 citations
ABSTRACT Background Transcriptomic adaptations of ageing skeletal muscle to concurrent resistance training (RT) and high‐intensity interval training (HIIT) remain insufficiently characterized. We investigated the effects of a 12‐week concurrent RT + HIIT intervention on the vastus lateralis transcriptome in middle‐aged...
A. Guadalupe-Grau, D. Gudra, D. Lismane et al.· Journal of Cachexia, Sarcope...· 0 citations
Investigating the utility of genome-wide association study - derived PRS and pathway-specific PRS in the Latvian population and demonstrating superior discrimination compared to pathway-specific PRS found incorporation of PRS enhances early-onset CAD risk prediction.
E. Kanašniece, Elita Ozola, L. Bardina et al.· American Heart Journal Plus:...· 0 citations
The findings of this cross-sectional observational MRI study support further study of venous sinus morphology as a potential contributor to MRI-visible PVS burden, while longitudinal and flow-sensitive studies are needed to clarify causality and glymphatic clearance mechanisms.
Gvido Kārlis Skuburs, Kristīne Šneidere-Pītersa, A. Platkājis et al.· Diagnostics· 0 citations
Although no subgroup-specific signatures were confirmed after correction for multiple testing, several candidate miRNAs were identified, supporting further investigation of miRNA-based biomarkers in CSU.
Lāsma Lapiņa, Katrīna Daila Neiburga-Vīgante, L. Gailīte et al.· Frontiers in Immunology· 0 citations
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