L. Gaetani

Cerebrospinal fluid dopa-decarboxylase is a biomarker of dopaminergic dysfunction

Application of unsupervised and supervised machine learning approaches to blood-based biomarkers of Alzheimer’s disease in a memory clinic cohort

Blood-based biomarkers (BBMs) are promising tools to facilitate biological diagnosis of Alzheimer’s Disease (AD). Establishing reliable cutoffs for BBMs represents a major issue for real-world implementation and the investigation of combined BBM approaches is limited. Our aim is to test different machine learning...

Cerebrospinal fluid and plasma biomarkers in idiopathic normal pressure hydrocephalus: comparison with Alzheimer's and Parkinson's diseases

Background Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurological disorder whose diagnosis is complicated by clinical overlap with neurodegenerative diseases. Fluid biomarkers may provide insight into disease mechanisms and support differential diagnosis. Methods We performed a small e...

Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practice

The principles of harmonized reporting for Alzheimer’s disease biomarkers and a structured framework for standardized clinical neurochemistry reports are discussed and a structured framework for standardized clinical neurochemistry reports is proposed.

Beyond diagnosis: can fluid tau biomarkers stage Alzheimer’s disease? Lessons from down syndrome

Plasma tau biomarkers, particularly plasma p-tau217, have consistently shown excellent diagnostic performance across the AD continuum, recently culminating in regulatory approval of plasma p-tau217-based assays in both the USA and Europe.

Can the integration of blood-based biomarkers into Alzheimer’s disease diagnosis revolutionize the field?

The authors critically appraise the current evidence supporting plasma phosphorylated tau at threonine 217 (p-tau217) as the leading BBM for AD, and highlight current limitations, unresolved challenges, and future perspectives for the integration of plasma biomarkers into routine clinical practice.

Thalamocortical connectivity and nucleus-specific thalamic dysfunction in temporal lobe epilepsy: an integrative review

Overall, the available evidence supports a transition from a predominantly hippocampocentric framework toward a distributed thalamocortical network model of TLE, and emerging longitudinal evidence further suggests that thalamocortical networks may undergo postoperative reorganization following successful epilepsy surge...

Circadian rhythm disruption and multiple sclerosis: The role of affective symptoms and temperamental traits.

Systematic assessment of mood and circadian rhythms may offer a more comprehensive framework for identifying clinically relevant chronobiological disruption in patients with multiple sclerosis.