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Author

L. Fu

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Aug 2026

DHCR24+ tumor epithelial cells drive cisplatin resistance in bladder cancer by enhancing cholesterol metabolism to activate lipid raft-associated MAPK signaling

This study characterizes a specific DHCR24+ tumor epithelial subpopulation that orchestrates cisplatin resistance via the "cholesterol-lipid raft-MAPK" axis and establishes a clear mechanistic link between cholesterol metabolism and cisplatin sensitivity.

Yuan-Qiao Zhao, Zhuo Xing, Meng-Meng Wang et al. · 0 citations
Open access Aug 2026

TFE3‐DualNet: An Interpretable Foundation Model‐Based Deep Learning Ensemble for Diagnosing TFE3‐Rearranged Renal Cell Carcinoma From Whole‐Slide Images in a Two‐Center Cohort

TFE3‐rearranged renal cell carcinoma (TFE3‐rRCC) is a rare, aggressive subtype that predominantly affects adolescents and young adults. Its marked morphologic heterogeneity can delay recognition and downstream confirmatory testing.

Yu-Hang Chen, Quanhui Xu, Haohua Yao et al. · 0 citations

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