Whether reversal of biological age and/or aging is possible is among the most actively debated topics in the field of aging. Here, we consider the meaning of biological age reversal and its burden of proof, focusing on foundational issues and the language we use to debate these questions.
J. Poganik, A. Moldakozhayev, Jamie N. Justice et al.· Cell Metabolism· 0 citations
Sex differentially shapes aging, neurodevelopment and neurodegenerative diseases such as Alzheimer's disease (AD). However, most biological aging clocks (artificial intelligence-predicted age minus chronological age) were trained on sex-pooled samples and implicitly assume sex invariance.Here we developed 38 sex-specif...
An integrated wet-lab and computational platform designed to overcome barriers to population-scale long-read RNA sequencing, providing a scalable, community-ready framework for isoform-resolved transcriptomics in neurodegeneration, aging, and complex brain disease.
C. Kouam, Jackson Mingle, Pilar Álvarez Jerez et al.· bioRxiv· 0 citations
It is proposed that the age-associated reduction in LANCL1-AS1 contributes to impaired mitochondrial function and reduced myogenic capacity in aging skeletal muscle.
Jen-Hao Yang, Elizabeth K. Izydore, K. Mazan-Mamczarz et al.· bioRxiv· 0 citations
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