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Open access Sep 2026

The Association Between Obstructive Sleep Apnea and the Circadian Rest-Activity Rhythm: A Cross-sectional Analysis of the ELSA-Brasil Cohort.

OBJECTIVES To investigate the potential association between obstructive sleep apnea (OSA) and the circadian rest-activity rhythm. METHODS Active or retired employees aged 35-74 years from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) were eligible for inclusion. Participants underwent a standardized...

A. Targa, I. Benítez, Mario Henríquez-Beltrán et al. · 0 citations
Open access Oct 2026

Intensive blood-pressure control for the prevention of major cardiovascular events in stroke patients: rationale and design of the OPTIMAL-STROKE trial

Abstract Background In high cardiovascular risk populations without prior stroke, intensive blood pressure (BP) lowering confers greater reductions in cardiovascular events than standard targets. However, optimal BP targets in patients with ischaemic stroke (IS) or TIA remain uncertain. The primary objective of the OPT...

G. Silva, M. J. Machline-Carrion, K. Santo et al. · 0 citations
Sep 2026

Effects of obstructive sleep apnoea treatment on cardiovascular and sleep health in bed partners: the sleep partners clinical trial.

BACKGROUND It remains unclear whether obstructive sleep apnoea (OSA) and its treatment influence cardiovascular and sleep health in bed partners. METHODS In this placebo-controlled trial, patients with moderate/severe OSA who had bed partners were randomly assigned to receive continuous positive airway pressure (CPAP...

S. Giampá, Sofia F. Furlan, T. Macedo et al. · 0 citations

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