Endangered species often suffer from genetic threats such as inbreeding depression, the accumulation of mutation load and the general loss of genetic diversity, which may deprive them from future adaptation. Since the genetic make-up of a species is strongly affected by its evolutionary past, however, interspecific com...
Xenia Wietlisbach, Mathieu Robin, Andreas Füglistaler et al.· bioRxiv· 0 citations
A previously undescribed bovine mitochondrial clade, termed yak X, was recently discovered in Pleistocene Asia.1 However, the genome-wide relationships of this lineage to other bovines remain unclear. Here, we present 20 Middle and Late Pleistocene yak X nuclear genomes that were recovered from Denisova Cave and other...
Jonas Oppenheimer, Alexandre Gilardet, M. Kozlikin et al.· Current Biology· 0 citations
The woolly rhinoceros was a prominent Ice Age megafaunal species, and there is limited knowledge regarding its origin and responses to past glacial cycles. We sequenced 29 mitochondrial and 14 nuclear genomes from Pleistocene specimens across Eurasia and modeled the species' habitats over the past 500,000 years. Our re...
X. Lei, J. Ruan, Xue Liang et al.· Science· 0 citations
A multiplex genome engineering pipeline capable of introducing up to eleven genomic modifications across seven different genes simultaneously in viable founder mice is established, advancing methods of rapid establishment of complex genetic models, with a wide array of applications.
Rui Chen, M. Coquelin, Kanokwan Srirattana et al.· Cell Reports Methods· 0 citations
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