Author

L. D. de Fraga

2 papers indexed here

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Open access Aug 2026

Sex-specific effects of therapeutic hypothermia on short- and long-term microglial and astrocytic reactivity after severe neonatal hypoxia–ischemia

Therapeutic hypothermia (TH) is the standard treatment to reduce mortality and neurological impairments after neonatal hypoxia–ischemia (HI). However, TH does not fully suppress neuroinflammation, leading to persistent neuroinflammatory responses that may exacerbate brain injury and limit TH efficacy. In addition, the...

Ricardo Ribeiro Nunes, João Vitor Miotto Tauffer, B. B. Martins et al. · Metabolic brain disease · 0 citations

Review Open access Aug 2026

Ketone bodies in the developing brain: Sex-specific metabolic pathways during the neonatal period.

The developing central nervous system (CNS) relies on tightly regulated metabolic substrates, including glucose, lactate, and ketone bodies (KBs), to energy demands, brain maturation and neural circuit formation. Disruptions in substrate flow availability during early life can lead to long-lasting brain functional and...

K. F. Campos, D. Machado, A. Vizuete et al. · Life Science · 0 citations