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Open access Sep 2026

Succinate dehydrogenase (SDHB, SDHC, SDHD) gene variants significantly modify clinical outcomes in paraganglioma-pheochromocytoma but have a limited impact on head and neck paraganglioma.

PURPOSE Succinate dehydrogenase (SDH) gene variant types differentially influence risk for thoracic-abdominal paraganglioma-pheochromocytoma (PPGL) and head and neck paraganglioma (HNPGL), but quantitative correlations are lacking. METHODS In this genotype-phenotype study of 2706 patients with PPGL-HNPGL and SDH vari...

J. Bayley, Lauren Fishbein, S. Akker et al. · 0 citations
Open access Aug 2026

AD18 Integrated steroidomic and untargeted metabolomic profiling reveals distinct circulating signatures of adrenocortical carcinoma

Adrenal tumours display marked biological heterogeneity, making the distinction between benign and malignant lesions challenging. Liquid chromatography–high-resolution mass spectrometry (LC-HRMS) enables simultaneous investigation of steroidomic and broader metabolomic alterations. To identify integrated c...

G. Galante, T. Sénard, A. Gennai et al. · 0 citations

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