Open access
Jul 2026
p53-R280S mutation confers lenvatinib resistance in hepatocellular carcinoma via Bcl-2-mediated anti-apoptotic signaling
RNA sequencing of lenvatinib-resistant HCC cell lines revealed p53 dysregulation, and sanger sequencing identified the p53 R280S missense mutation, which was shown to enhance lenvatinib resistance in vitro and in vivo.
Niangmei Cheng, Ke-Xin Liu, Xin Qi et al.
· Molecular and Cellular Bioch... · 0 citations