Integrative Systems Genomics and Pharmacology Define Shared Immune–Vascular Programs and Prioritize an Experimentally Testable Candidate Linking Sleep Loss to Human Atherosclerosis
Background: Sleep loss is epidemiologically linked to atherosclerotic cardiovascular disease, yet shared-transcriptome studies typically intersect differentially expressed gene lists and treat the overlap as a shared response, assuming rather than testing directional agreement. Methods: Controlled human sleep restricti...