Freezing of gait (FoG) in Parkinson’s disease is clinically heterogeneous, yet wearable-sensor studies predominantly focus on binary FoG detection. We investigated whether right-ankle inertial signals can characterize clinically meaningful FoG manifestations within a three-stage conditional framework. Accelerometer and...
A. Ielo, L. Bonanno, A. Quartarone et al.· Bioengineering· 0 citations
White matter (WM) degeneration is an important feature of aging and Alzheimer’s disease (AD). Neurite orientation dispersion and density imaging derived from diffusion tensor imaging (NODDI-DTI) is a technique that allows the estimation of neurite density index (NDI) and orientation dispersion index (ODI) in WM fro...
Giovanni Restuccia, A. Ielo, V. L. Buono et al.· Scientific Reports· 0 citations
The findings support the potential role of structural MRI biomarkers combined with interpretable ML approaches for the classification of cognitive impairment and the integration of demographic variables improved model performance, particularly in binary discrimination tasks, whereas multiclass classification remained m...
The severity of depressive symptoms were strongly associated with reduced functional autonomy and the importance of early diagnosis and targeted interventions for depressive symptoms to improve patient management in everyday life is highlighted.
Irene Cappadona, Maria Pagano, Anna Anselmo et al.· Neurodegenerative Disease Ma...· 0 citations
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