DNA methylation (DNAm) plays a critical role in Alzheimer's disease (AD). Previous epigenome-wide association studies using 450K arrays captured limited CpG coverage and often focused on a single neuropathological measure. Here we profiled DNAm in 1,250 postmortem prefrontal cortex samples from the Rush Alzheimer's Dis...
G. Miao, Cheng Gao, Lei Yu et al.· Nature Aging· 0 citations
INTRODUCTION: Cognitively stimulating activity (CSA) is associated with cognitive health, but whether associations with cognitive change differ by life stage and sex remains unclear. METHODS: Data were drawn from Rush cohorts. Participants were 2,614 adults aged 65 years and older (1,965 females; 649 males). CSA during...
S. Goulding, S. Raeesi, J. A. Anderson et al.· medRxiv· 0 citations
A single-nucleus transcriptomic atlas spanning the human lifespan is used to show that the dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development, relative stability in midlife and selective molecular reactivation in la...
Hui Yang, Tereza Clarence, Madeline R. Scott et al.· Nature· 4 citations
In older Black adults, circulating inflammatory proteins were linked to cognition, reinforcing the role of systemic inflammation as a potential driver of neurodegeneration in this population.
Anat Yaskolka Meir, H. Adeola, S. Tasaki et al.· Brain : a journal of neurolo...· 0 citations
By analyzing associations between community-level factors and inflammation-related proteins, this study provides new molecular insights into how social context may relate to biological risk, identifies proteomic patterns that could inform the development of community-level interventions, and underscores the utility of...
Anat Yaskolka Meir, H. Adeola, S. Tasaki et al.· BMC Medicine· 0 citations
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