Alzheimer's disease (AD) is the most common cause of dementia, with global case numbers projected to reach 153 million in 20501. AD is highly heritable, with twin-based heritability estimates of 60-80%2. Although 1,200 causal loci are predicted to exist for AD3, approximately 80 loci have been associated with AD in two...
E. Uffelmann, D. Wightman, S. Bahrami et al.· Nature· 0 citations
Some of the advantages of familial data using the Norwegian Mother, Father and Child Cohort Study (MoBa), a population-based cohort of parents and offspring with extensive genotype data, are illustrated along with broad and longitudinal phenotyping of health and functioning.
E. Corfield, A. Shadrin, O. Frei et al.· Nature· 3 citations
Multimodal integration of cognitive, neuroimaging, and polygenic data in the MHS-RWD tool yields strong discrimination for both early diagnosis of dementia and AD differential diagnosis, which could support etiologically informed dementia decisions in real-world settings, with potential utility in primary care.
T. T. Filiz, V. Fominykh, K. Persson et al.· medRxiv· 0 citations
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