Author

L. Ambrosio

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Review Open access Sep 2026

AO Spine Clinical Practice Recommendations: When to Operate in Lumbar Disc Herniation

Study Design Literature review with consensus clinical recommendations. Objective To review key studies on surgical vs. non-operative treatment for lumbar disc herniation (LDH) and present recommendations for how the practicing clinician should use this evidence. Methods Two randomized controlled trials (RCTs), two RCT...

G. Vadalà, L. Ambrosio, Xiao-Long Chen et al. · Global Spine Journal · 0 citations

Review Open access Aug 2026

Irisin in Cartilage Homeostasis: Molecular Mechanisms and Therapeutic Implications for Osteoarthritis

Osteoarthritis (OA) is a leading cause of disability worldwide, characterized by progressive joint degeneration driven by extracellular matrix (ECM) breakdown, chondrocyte apoptosis, and chronic low-grade inflammation. Despite the availability of several pharmacological and non-pharmacological interventions, no current...

Raffaella Rosy Vescio, M. Fiordalisi, L. Ambrosio et al. · Journal of Functional Morpho... · 0 citations