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L. Agnelli

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Open access Sep 2026

Lynch syndrome–associated urothelial carcinoma: clinical and molecular findings from a single-institution cohort

Lynch syndrome–associated urothelial carcinoma (LS-UC) is a rare and undercharacterized clinical entity. While FGFR3 alterations are well described in sporadic urothelial carcinoma, their prevalence and clinical implications in LS-UC remain unclear. We aimed to provide a comprehensive clinical and molecular characteriz...

A. Rametta, M. Barella, A. Scardino et al. · 0 citations
Open access Aug 2026

Comprehensive genomic profiling of mucosal melanoma reveals novel fusion transcripts and dysregulation of cell‐cycle, MAPK, and PI3K pathways

It is proposed that MEK inhibitors may represent a relevant therapeutic option for BRAF fusions and non‐V600 BRAF mutant tumours, providing a novel strategy for this challenging disease.

Matilde Monti, Martina Brigida Romanello, L. Agnelli et al. · 0 citations
#artificial intelligence Open access Sep 2026

Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC

In a large international real-world study of non-small cell lung cancer, a multimodal explainable AI model outperformed established biomarkers for immunotherapy outcome prediction and improved physician decision-making.

A. Prelaj, V. Mišković, Matteo Sacco et al. · 1 citation

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