Engineered natural killer (NK) cells expressing chimeric antigen receptor (CAR) represent a promising alternative to CAR T-cell therapy due to their allogeneic potential. However, current CAR NK cell production relies on lentiviral or retroviral transduction to achieve stable CAR expression, requiring complex, multiste...
Ha Yeon Park, Seon-Jeong Kim, Kyuree Kim et al.· ACS Applied Materials and In...· 0 citations
Immune cell-based therapies have transformed immuno-oncology by converting living cells into therapeutic agents able to recognize, infiltrate, and eliminate diseased tissues. While T cell, NK cell, and dendritic cell platforms have delivered meaningful clinical advances, in solid tumors and chronically inflamed tissues...
Eunha Kim, Min-A Park, Kyobum Kim· Biotechnology Advances· 0 citations
An antitumor peptide-based delivery platform in which both termini of a stapled p53 α-helix are linked via a disulfide bond, thereby repurposing nonpolar residues originally involved in target protein (hDM2) binding as a hydrophobic block that drives co-assembly with doxorubicin.
Jae Yun Lee, Moo Chang Park, Sung-Chan Choi et al.· Small· 0 citations
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