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Kylene M. Harold

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Open access Sep 2026

PFKFB2 Gates a Relationship Between Cardiac Glycolytic Regulation and Electrophysiological Function.

BACKGROUND The cardiac isoform of PFKFB2 (phosphofructokinase-2/fructose 2,6-bisphosphatase) is the heart's strongest glycolytic regulator but is degraded in the absence of insulin signaling. This makes PFKFB2 loss critical to understand in metabolic heart disease, of which impaired insulin signaling is a hallmark. Pro...

Kylene M. Harold, Harris E. Blankenship, Keaton E. Minor et al. · 0 citations

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