Author

Kwok-Wai Lo

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Open access Jul 2026

Long-read sequencing reveals widespread novel splicing and neojunction-derived neoantigens in nasopharyngeal carcinoma

Long-read sequencing is employed to generate a high-resolution, isoform-level transcriptomic atlas from a cohort of 14 NPC tumor samples and four immortalized nasopharyngeal epithelial cell lines, and a new class of noncanonical neoantigens with significant potential for developing personalized cancer vaccines for NPC are identified.

Yi Shuai, Hualiang Yao, Bo Wang et al. · Genome Research · 0 citations

Review Open access Aug 2026

The roles of chromatin remodeling and 3D genome organization in cancers: from mechanistic insights to emerging treatment options

A comprehensive synthesis of the mechanisms and functional roles of classical chromatin remodelers within both physiological and neoplastic contexts is provided and a hierarchical framework that distinguishes between 'first-level' and 'higher-order' chromatin remodeling is proposed.

Chuqiao Luo, Ninglin Xia, Shin-Yee Hui et al. · Molecular Cancer · 0 citations