Metabolomics provides functional molecular readouts of disease phenotypes, therapeutic responses, and tissue microenvironments, but its extension to low-volume, single-cell, and spatially resolved samples remains analytically challenging. Laser desorption/ionization mass spectrometry (LDI-MS) offers a rapid, direct, an...
Yi Gu, Yan-Xi Yang, Jiao Wu et al.· Nanoscale· 0 citations
Currently, there remains a lack of effective prognostic biomarkers specifically for ARDS patients.
We conducted a retrospective study profiling plasma metabolomics (ARDS = 55, non-ARDS = 37) via high-throughput NPELDI-MS. Machine learning (LR, SVM, NN) developed age-stratified prognostic models (< 65 vs. ≥...
ABSTRACT The poor prognosis of liver cancer (LC) highlights the urgent need for more effective strategies for early detection. We conducted a large, multicenter study to develop and validate a serum metabolic signature for LC diagnosis. Using high‐throughput nanoparticle‐enhanced laser desorption/ionization mass spectr...
Yong-Jie Xu, Jia-Chen Wang, Chun-Meng Ding et al.· Advancement of science· 0 citations
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