A Coding Single Nucleotide Polymorphism in β2-Glycoprotein I (APOH) is Associated with Increased Autoantibody Levels but Reduced Venous Thromboembolism Risk
Objective: Anti-β2-glycoprotein I (anti-β2GPI) antibodies are central to antiphospholipid syndrome. The APOH locus has been associated with anti-β2GPI, but the causal variant and thrombotic risk implications remain unclear. Methods: We performed a multi-ancestry genome-wide association study (GWAS) of quantitative tota...