Open access
Aug 2026
Rb-driven transcription limits its tumour-suppressive effects in breast cancer
The retinoblastoma protein (Rb) is a tumour suppressor best known for repressing E2F transcription factors and halting cell cycle progression1. In hormone receptor-positive (HR+) breast cancer, CDK4/6 inhibitors activate Rb by preventing its phosphorylation, forming a key component of current endocrine therapy regimens...
April C. Watt, Antonio Ahn, Catherine Blyth et al.
· Nature · 2 citations