Microglia play essential yet poorly understood roles in brain development, including axon guidance, regulation of neurogenesis, and pruning of neuronal projections. Congenital hydrocephalus (CH), characterized by enlarged cerebrospinal fluid (CSF)-filled ventricles, is a leading cause of pediatric brain surgery, but it...
Phan Q. Duy, Benjamin C. Reeves, Huan-Xing Sun et al.· Journal of Clinical Investig...· 0 citations
Diagnostic testing and neurosurgical management involving CSF shunting in patients with idiopathic normal pressure hydrocephalus (iNPH) offers a unique, ethically sustainable opportunity to study the aging human brain. The common co-occurrence of neurodegenerative pathologies such as amyloid-β plaques and neurofibril...
Heikki E. M. Lukkarinen, A. Luikku, Antonios Dougalis et al.· Alzheimer's Research & T...· 0 citations
Exome sequencing may complement surgical evaluation of children with sporadic CM1, particularly when accompanied by neurodevelopmental concerns, informing prognosis and family counseling, and implicating genetically encoded dysregulation of cerebellar development as a central disease mechanism.
Neel H. Mehta, Garrett Allington, Evan Dennis et al.· Brain : a journal of neurolo...· 0 citations
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