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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Kristina Håkansson

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#protein folding Sep 2026

Proton-Transfer Reactions Modulate Protein Ion Structure to Yield Altered Backbone Cleavage Pathways in Top-Down Mass Spectrometry

Proton-transfer reaction (PTR) has emerged as a powerful tool for top-down proteomics. It can mitigate spectral congestion and improve the signal-to-noise ratio of electrospray ionization (ESI)-generated intact proteins. We hypothesized that charge removal during PTR of Coulombically unfolded, denatured ESI ions indu...

Marek Polák, Lissa C. Anderson, Kristina Håkansson et al. · 0 citations

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