ABSTRACT Purpose Diabetic polyneuropathy (DPN) is a debilitating complication of diabetes that affects motor nerves and may impair skeletal muscle health. This study investigated skeletal muscle proteomic alterations associated with DPN compared with type 2 diabetes without DPN (T2D) and healthy controls (CON). Experim...
F. Thybo, K. Khan, Jesper Emil Jakobsgaard et al.· PROTEOMICS - Clinical Applic...· 0 citations
Fibro-adipogenic progenitors (FAPs) have emerged as central regulators of the skeletal muscle homeostasis and the muscle microenvironment. However, the role of FAPs in the context of exercise-induced muscle hypertrophy remains largely unexplored. Here, we utilized six weeks of blood flow restricted resistance exercise...
Jakob Wang, Jonas Brorson, Søren Kuhdal et al.· bioRxiv· 0 citations
The findings reveal that mechanosensitive anabolic signaling is differentially affected by aging, and suggests that age-related deficits observed in vivo may, at least in part, arise from systemic influences rather than intrinsic defects adhering to mTORC1 mechanotransduction.
J. B. Kristiansen, Jacob Andresen, Jesper Emil Jakobsgaard et al.· Experimental Gerontology· 0 citations
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