Development of a drug delivery vehicle protein exhibiting high binding affinity and low leakage of the anti-cancer drug SN-38.
It is demonstrated that simple amino acid substitutions in L-PGDS can optimize drug binding, improve solubility, and suppress drug release, thus providing a basis for affinity-driven design of protein-based DDSs.
Masatoshi Nakatsuji, Haruka Muroya, Rina Okubo et al.
· International Journal of Bio... · 0 citations