Open access
Oct 2026
Astrocytic cathepsin D promotes α-synuclein processing and Lewy neurite-like aggregate maturation.
Parkinson's disease (PD) and related synucleinopathies are marked by the accumulation and propagation of α-synuclein (α-syn) aggregates, a process primarily studied in neurons. Whether astrocytes actively contribute to α-syn processing and intercellular transfer remains unclear. Here, using a physiologically relevant n...
Hiroshi Hanafusa, Kota Ohashi, Hiromu Shojima et al.
· EMBO Reports · 0 citations