Nearly a century ago, restricting diet during early-life periods was suggested to extend lifespan in rats and in Daphnia1,2. The effect of juvenile diet on adult physiology and lifespan has subsequently been described in other model organisms, including fruit flies3, 4–5 and mice6, 7–8; however, its mechanism remains p...
Hina Kosakamoto, Rina Okada, Clive S. Barker et al.· Nature· 2 citations
Although extracellular vesicles (EVs) facilitate selective molecular exchange between cells, their low yields and inherent heterogeneity limit translational applications. Cell‐derived nanovesicles (CDNs), produced by mechanical extrusion of donor cells, offer a scalable alternative while retaining key membrane features...
Eisuke Kanao, Ryosuke Mizuta, Saki Tarao et al.· Small Methods· 0 citations
MeadBRYO is presented: a method for continuous stable isotope labeling (SILAC) of newly synthesized proteins throughout the live embryo at the hour-timescales of developmental phenotypes, thereby accessing the proteome of neurogenesis in the forebrain ex utero.
Marta Couce-Iglesias, Eleonora Oliani, R. Kerridge et al.· bioRxiv· 0 citations
SPIN1 uses a histone-state-based mechanism to identify and repress young TEs in pluripotent cells, mechanistically distinct from its germline mode in which SPIN1 cooperates with the PIWI–piRNA pathway to promote DNA methylation, illustrating how a single histone reader engages distinct silencing machineries across cell...
Hiromi Yamada, Chikara Takeuchi, Clive S. Barker et al.· bioRxiv· 0 citations
A ribosome tagging and purification strategy is developed that bypasses the prolonged turnover of ribosomal proteins, enabling ribosome profiling with one-hour temporal resolution after neural stimulation, and uncovered previously unknown activity-dependent alternative translation with functional implication, such as t...
Nayan Suryawanshi, Hitoshi Uchida, R. Endo et al.· Nature Communications· 0 citations
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