Open access
Sep 2026
Mitochondrial ATP promotes T cell differentiation through chromatin accessibility.
Immune elimination of chronic infection or cancer requires cytotoxic CD8+ T cells that adopt and maintain an effector phenotype. Cytotoxic T cell function is a bioenergetically demanding process. Here, we report the ability of D-α-hydroxybutyrate (DAHB) to act as a signaling molecule that increases mitochondrial ATP pr...
Charles Ng, Tak-Shun Fung, Da-Yi Li et al.
· Cell · 0 citations